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After new CIA recruit, Kelley Chandler (Polish) is seriously injured during a mission, surviving only on life support, his wife Tess (Agron), a former CIA operative, becomes determined to find out what happened to her husband. As the details of Kelley's last mission unravel, showing that his accident was an inside job, Tess puts everything on the line to keep Kelley out of harm...。燥热枯燥的长途旅行，怪物卡车司机“锈钉”（肯·科齐格 Ken Kirzinger 饰）的血腥旅程仍未结束，17号公路上布满残肢断体，娱乐着他的邪恶趣味。某个平凡的路边小餐馆，奥斯汀（Gianpaolo Venuta 饰）、米克（Ben Hollingsworth 饰）、爱丽莎（Leela Savasta 饰）、鲍比（Jake Manley 饰）和茱尔（Kirsten Prout 饰）等五个准备参加公路汽车拉力赛的青年男女正在讨论行车路线，他们向邻桌打听17号公路存在与否，却得知了“屠杀小巷”的传言和警告。 无所畏惧的年轻人当然不信这个邪，他们快意上路，并遭遇“锈钉”的卡车。年轻人仗着汽车性能的优势，恣意戏耍“锈钉”，但却惹到了一个绝不能随便招惹的恶魔……。林天为了国家科研项目，销声匿迹五年，潜心研究。可就在项目成功当天，林天却接到妻女出事的电话，她们被权势滔天的组织抓了起来，要做恐怖的基因改造试验。林天一怒之下，带着研究出来的黑科技前往救人，摧毁了樱花国一件野心勃勃的计划。。